Comparison of preoperative endometrial biopsy grade and final pathologic diagnosis in patients with endometrioid endometrial cancer [Endometrioid endometriyum kanserli olgularda preoperatif endometriyal biyopsi grade ile postoperatif patolojik deǧerlendirmenin karşi{dotless}laşti{dotless}ri{dotless}lmasi{dotless}]

Objective: to compare preoperative grading in endometrioid endometrial cancer with the final pathologic assessment of the hysterectomy specimen. the second objective of the study was to determine a high risk group who will be upgraded in the postoperative evaluation. material and methods: a total of 335 patients with endometrioid endometrial cancer were retrospectively reviewed between june 2000 and january 2011. all pathology results were pre- and postoperatively reviewed at two institutions,and all patients underwent surgical therapy. sensitivity,specificity,positive and negative predictive values and accuracy rates were calculated for all grades in the preoperative assessment. results: the mean age of the patients was 56.2±9.6 and the vast majority of the patients were postmenopausal (n=239,71.3%). figo grade was determined to be greater in 75 patients in the final hysterectomy specimen. fifty-five (32.9%) of the patients with preoperative grade 1 were found to be grade 2 and 3.6% of them were upgraded to grade 3. fourteen of the patients with grade 2 (11.4%) were found to be grade 3. the accuracy rates of the preoperative grade assessment with endometrial sampling were 75.5%,66.2% and 88.3% for grades 1,2 and 3,respectively. there were no statistically significant differences in the preoperative demographic characteristics between patients with or without upgraded tumors. conclusion: a high percentage of preoperatively diagnosed grade 1 tumors were upgraded in the postoperative evaluation. the patients who would have been upgraded after hysterectomy could not have been predicted preoperatively using the characteristic features. © 2012 by the turkish-german gynecological education and research foundation.