Does Aquaporin-1 expression have clinical significance in serous epithelial ovarian cancer? [Aquaporin-1 ekspresyonunun seröz epitelyal over kanserinde klinik önemi var mi{dotless}di{dotless}r?]

Objective: to assess the relationship between aquaporin-1 (aqp1) expression and clinicopathological variables in serous epithelial ovarian cancer (eoc). material and methods: serous eoc cases treated in our institution between january 2007 and december 2009 were included in the study. a semi-quantitative immunohistochemical method was used to determine aqp1 expression levels,intratumoral microvessel density (imd) and aqp1/imd ratios. the relationship between these parameters and clinicopathological variables were assessed. p values less than 0.05 was considered statistically significant. results: a total of 55 cases of serous eoc were included in the study. aqp1 was strongly expressed in the membranes of microvessels and small vessels within all tumor tissues. in a few cases,aqp1 expression was also observed in the membrane of interstitial cells and in individual tumor cells. a positive correlation was detected between preoperative ca125 levels and the expression of aqp1 (r: 0.277,p<0.05). aqp1 expression was similar between figo stage i-ii and figo stage iii-iv cases (p > 0.05). a significant relationship did not exist between aqp1 expression and figo stage,lymph node metastasis or ascites volume (p>0.05). conclusion: in this study,aqp1 expression did not have a significant association with important clinicopathological variables in serous eoc. future studies are needed to determine aqp1 expression in other histological types of eoc. © 2013 by the turkish-german gynecological education and research foundation.