Antenatal diagnosis and outcome of agenesis of corpus callosum: A retrospective review of 33 cases

Objective: to present antenatal sonographic findings and postnatal outcome of a population of foetuses diagnosed with agenesis of corpus callosum. material and methods: the database of our ultrasound laboratory was retrospectively searched for cases of agenesis of the corpus callosum suspected at antenatal sonography between 2002 and 2012. the following variables were assessed: maternal age,gestational age at diagnosis,gender,any additional cerebral and extra-cerebral malformations,results of karyotype analysis and pregnancy and foetal/neonatal outcomes. results: during the study period,33 foetuses with agenesis of the corpus callosum were identified antenatally,with a male preponderance. the mean maternal age was 28.48 years. in all cases,pre/postnatal mri and/or necropsy were performed in order to confirm the diagnosis. among those,there were additional brain findings in 23 (69.7%) and additional extra-cerebral anomalies in 3 (9.1%) foetuses. karyotype analysis was performed in 21 of 33 (63.6%) cases. as for pregnancy outcome,the pregnancy was terminated in 14 (42.4%) of the remaining 19 foetuses; eighteen (54.5%) were delivered near term and one (3.1%) who was delivered prematurely died during the neonatal period. conclusion: the diagnosis of congenital brain malformation is a challenging issue,since additional findings have a considerable effect on prognosis; detailed examination with genetic counselling should be performed. © 2014 by the turkish-german gynecological education and research foundation.