Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy

Objective: the presence of deleterious mutations in breast cancer (brca)-1 or brca-2 gene has a decisive influence on the development of various types of neoplasms,such as breast,ovarian,tubal,and peritoneal cancers. primary peritoneal cancer is an aggressive malignancy which,due to the absence of a specific screening test,cannot be diagnosed in its early stages. as a risk-reducing option,prophylactic bilateral salpingo-oophorectomy and mastectomy are often proposed in brca gene carriers. the effectiveness of a preventive surgical treatment is,however,unclear in the development of peritoneal cancer. material and methods: an extensive electronic search was performed in pubmed,scopus,and cochrane databases. results: the total number of patients who underwent prophylactic bilateral salpingo-oophorectomy was 1,830,of whom 28 presented with peritoneal cancer (1.53%). the age of the included patients ranged from 48 to 61 years. brca-1 was present in 9 out of 28 patients and brca-2 in 2 patients,while the type of brca was unclear in 17 patients. salpingo-oophorectomy was performed in 23 out of 28 patients,while oopho-rectomy was carried out in 5 patients. the interval from initial risk-reducing surgical treatment to the presentation of peritoneal cancer ranged from 12 to 84 months. conclusion: modification of the follow-up guidelines and increase in healthcare providers’ awareness may reduce the risk of peritoneal cancer. © 2016 by the turkish-german gynecological education and research foundation.