Predictive values of maternal serum PAPP-A level,uterine artery doppler velocimetry,and fetal biometric measurements for poor pregnancy and poor neonatal outcomes in pregnant women

Objective: to determine predictive values of maternal serum papp-a (mspapp-a) levels,uterine artery doppler velocimetry,and fetal biometric measurements (fbms) for poor pregnancy and poor neonatal outcomes. material and methods: this prospective cohort study was conducted on singleton pregnancies followed until delivery. pregnancy and neonatal outcomes were evaluated with respect to the mspapp-a level at the 11th–14th weeks,uterine artery doppler velocimetry at the 15th–18th weeks,and fbms at the 20th–24th and 28th–32nd weeks of pregnancy. results: one hundred fifty-eight women constituted the study group; 17 (10.75%) of them had at least one poor pregnancy outcome. the cut-off point of 0.72 multiple of the median (mom) for the papp-a level achieved a sensitivity of 82.4% and a specificity of 29.8% for poor pregnancy outcomes. the mean birth weight was significantly lower in the subgroup with a higher mean pulsatility index of uterine arteries (uapimean≥1.19) (p=0.025) as well as in the subgroup with a higher mean resistance index of uterine arteries (uarimean≥0.62) (p=0.013). when the subgroup of pregnant women under the risk of early-onset iugr according to fbms was compared to the low-risk group,statistically significant differences were seen in terms of pregnancy outcomes (p=0.045) and birth weight (p=0.011). conclusion: maternal serum papp-a level and fbms could be used for predicting pregnancy outcomes,while uterine artery doppler velocimetry and fbms could be used for predicting neonatal outcomes,specifically the birth weight. © 2016 by the turkish-german gynecological education and research foundation.