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IS IT POSSIBLE FOR THE 2-[(4-CHLORO-PHENYL)-(3,5-DIMETHYLPYRAZOL- 1-YL)-METHYL]-MALONIC ACID DIETHYL ESTER TO PRESENT A POTENTIAL CANDIDATE HIV-INTEGRASE INHIBITOR ON THE BASIS OF ITS O,N,O-LIGAND STRUCTURE
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نویسنده
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elmeskini ihsane ,toupet loic ,daoudi maria ,kerbal abdelali ,moreira diogo r. m. ,hadda taibi b.
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منبع
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journal marocain de chimie hétérocyclique - 2019 - دوره : 18 - شماره : 2 - صفحه:36 -45
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چکیده
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The titled new functionalized ligand of type 2-[(aryl)-(cycloaminilyl)-methyl]- malonic acid diethyl ester (4) is prepared in good yield through condensation of 3,5- dimethylpyrazole, with 2-arylidene-malonic acid diethyl esters 3. the structure of 4 was determined by spectral (ir, 1h nmr), elemental analyses and x-ray diffraction data. the molecular conformation shows two possible pockets ready to coordinate two metal atoms.
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کلیدواژه
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Polydentate O ,O-ligand ,b-amino dicarbonyl compound ,malonate ,Michael reaction ,aqueous medium
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آدرس
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université sidi mohammed ben abdellah, laboratoire de chimie organique, morocco, université de rennes, institut de physique, ipr, France, université sidi mohammed ben abdellah, laboratoire de chimie organique, Morocco, université sidi mohammed ben abdellah, laboratoire de chimie organique, Morocco, federal university of pernambuco, laboratory for the planning, synthesis and evaluation of pharmaceutical products, Brazil, université medicine 1ier, laboratoire de chimie des matériaux, Morocco
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پست الکترونیکی
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zouirchi2010@yahoo.fr
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Authors
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