SYNTHESIS AND BIOLOGICALEVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES

In the current work, novel heterocyclic derivatives containing 1,3,4-thiadiazole ring have been successfully synthesized through nucleophilic addition reaction, bythe condensation of 1,3,4-thiadiazole-2,5-diamines (1) as starting material with variouselectrophilic agents. the newly synthesized compounds were investigated for theirantimicrobial activities. structures of all the prepared compounds have been proved using(ftir), (1h-nmr) and (13c-nmr) spectra. the synthesized compounds were screened forantibacterial and antifungal activities against escherichia coli gram(-), salmonellatyphimurium gram(-), staphylococus aureus gram(+), enterococcus feaciumgram(+),streptocoque b(agalactiae)gram (+) and candida albicans. the synthesized compoundswere found to exhibit moderate to high antibacterial and antifungal efficiency against severaltested bacterial strains, using agar diffusion method and filter paper disc-diffusion method.ampicillin was used as positive control for all strains except candida albicans for whichnystatin was used. the prepared compounds manifested promising biological activity.