association of urinary triclosan and methyl-triclosan levels with predictive indicators of cardiovascular disease and obesity in children and adolescents in 2020 (case study: kerman, iran)

Background: exposure of children and adolescents to endocrine disrupting chemicals (edcs) causes the development of non-communicable diseases. triclosan (tcs) is a fat-soluble antimicrobial agent, and methyl-triclosan (mtcs) is the predominant metabolite of tcs. the increasing use of consumables tcs (toothpaste, mouthwash, personal care products) in human has raised concerns about human health. methods: the urinary concentrations of tcs and mtcs were measured by gc/ms. lipid profiles (tg, tc, ldl, and hdl), anthropometric parameters (wc, bmi z-score, and bmi), fbs, sbp, and dbp tests were performed on 79 children and adolescents. results: of 79 people included as the study population, 42 subjects (53.16%) were males. most of the study population as 32 subjects (40.50%) were obese. the mean concentrations of tcs and mtcs in the obese population were 5.47 ± 2.99 and 2.32 ± 1.04 μg/l, respectively. after adjusting for possible confounding factors, the results showed that a one-unit increase in dbp caused a 0.03 units increase in tcs levels in male subjects (p = 0.01). a one-unit increase in dbp also caused a 0.02 units increase in mtcs (p = 0.001). there was a significant relationship between tcs and hdl (or = 0.90, p = 0.005), ldl (or = 1.13, p = 0.01), and tg (or =1.05, p < 0.0001). there was also a significant relationship between mtcs and hdl (or = 0.88, p = 0.001), ldl (or = 1.03, p = 0.009), and tg (or = 1.04, p < 0.0001). conclusion: according to the results, there is a relationship between tcs, mtcs, and predictive indicators of cardiovascular diseases and obesity.