Assessment of leptin and resistin levels in non-obese multiple myeloma patients and their relation with Ig level and disease stage

Introduction: multiple myeloma (mm) accounts for approximately 0.8% of all cancer diagnoses and 0.9% of cancer deaths. leptin receptors were expressed on cd34+ cells. resistin receptors were expressed on inflammatory cells and pro-inflammatory cytokines increase the expression of resistin on monocytes. aim of work: to assess the level of leptin and resistin in non-obese multiple myeloma patients and to study their relation with ig level and disease stage. subjects & methods: 32 subjects were included; 16 patients diagnosed with mm and 16 healthy individuals served as control. all were subjected to history taking,clinical examination,routine laboratory investigations and leptin & resistin blood level. laboratory investigations were done for diagnosis and staging for mm patients. results: leptin was significantly higher in mm patients compared with the control group,unlike resistin which showed no significant difference between the two groups. a significant positive relation was found between igg level & leptin. similarly,a significant difference in leptin level has been observed between stage i & stage ii (higher in ii). conclusions: leptin may play a role in the pathogenesis of mm and its level may be changed in different stages. © 2014.