Treatment results of pediatric nasopharyngeal carcinoma,NCI,Cairo University experience

Background: investigate treatment outcome,prognostic factors and survival among selected group of egyptian pediatric nasopharyngeal carcinoma patients. patients and methods: thirty patients treated from non-metastatic nasopharyngeal carcinoma between 1997 and 2012 were retrospectively evaluated including: tnm staging,chemo-radiotherapy regimens. survival analysis was done using kaplan-meier survival curves. results: twenty-three males and 7 females (m:f 3.2:1) with median age of 14. years; 84% with stages iii/iv. neck node enlargement was reported in 90% (27/30). induction chemotherapy followed by radiotherapy was implemented in 80% of patients. mucositis (87%) was the commonest treatment related toxicity. nineteen patients (63%) were in cr with a median fu of 69. months (range 24-160). eleven patients had treatment local and distant failures (2 local,7 distant and 2 local/distant) at a median fu of 24 and 34. months respectively.5-year overall and event-free survival rates were 77% and 63% respectively. prolonged oap of rt. ≥ 50. days,hb. < 11. g% and t4 stage affected efs and oas on uva; while on mva; prolonged oap of rt. ≥ 50. days (p = 0.002) and t4 stage (p = 0.004) affected efs and only hb. < 11. g% (p = 0.019) affected oas. late toxicity was reported in 70% of irradiated patients. conclusion: radio-chemotherapy management for pediatric npc resulted in comparable treatment outcomes with tolerable late effects. response adapted radio-chemotherapy regimens in addition to the potential use of imrt should be recommended to decrease treatment related side effects. prolonged oap of rt. ≥ 50. days and low hb level were encountered as adverse prognostic factors; findings that need further investigation. © 2015 the authors.