Role of FDG-PET scan in the management of pediatric mature B cell non-Hodgkin's lymphoma. CCHE experience

Aim of work: to evaluate the sensitivity (se),specificity (sp),and predictive values (pv) of pet scan during management of pediatric mature b cell non-hodgkin's lymphoma (nhl) in comparison with conventional computed tomography (ct) scan. patients and methods: a retrospective study enrolled on pediatric nhl patients at children cancer hospital egypt (cche) during the period from july 2007 to the end of june 2013. results: for 115 pediatric patients diagnosed with mature b cell nhl,152 pet and 152 ct scans were done simultaneously. median age was 5.7 years. they were 85 males (74%) and 30 females (26%). one hundred twenty six scans (82.9%) were done for 100 (87%) burkitt lymphoma (bl) patients,while 26 scans (17.1%) were done for 15 (13.0%) patients with diffuse large b cell nhl (dlbc). nineteen examination (12.5%) were done before starting chemotherapy (group 1),107 (70.3%) at time of evaluation (group 2),and 26 (17.1%) during follow up (group c). overall sensitivity was 91.6% for pet and 70.0% for conventional ct (p = 0.02). specificity was 84.1% for pet and 58.9% for ct (p < 0.001). positive predictive value (ppv) for pet was 50%,while was 22% for ct scan (p < 0.001). negative predictive value (npv) for pet was 98%,and 92% for ct (p = 0.01). conclusion: pet scan is significantly more sensitive than conventional ct in the management of aggressive pediatric mature b cell nhl. pet negativity is an excellent indicator of tumor response. © 2016 national cancer institute,cairo university.