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Use of Novel Polyurethane Microspheres in a Curcumin Delivery System
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نویسنده
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hu y. ,li q. ,hong w. ,xing g. ,jiang q. ,lv w.
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منبع
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journal of spectroscopy - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Despite having a wide range of beneficial pharmacological effects,curcumin is characterized by poor water solubility and absorption. in this study,novel polyurethane microspheres containing curcumin (cur-pums) were prepared using carboxymethyl cellulose sodium to improve the bioavailability and prolong the retention time of curcumin. the prepared cur-pums were characterized by fourier transform infrared spectroscopy,scanning electron microscope,and ultraviolet spectrophotometer. the sustained-release effects of cur-pums were demonstrated using stability tests in vitro and in vivo pharmacokinetic studies following oral administration. we found that the stability of cur-pums was strongly affected by ph variation. further,compared with free curcumin,cur-pums showed significantly improved maximum concentration and half-life. © 2014 yongmei hu et al.
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آدرس
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national key laboratory of metastable materials science and technology,yanshan university,qinhuangdao, China, national key laboratory of metastable materials science and technology,yanshan university,qinhuangdao, China, qinhuangdao entry-exit inspection and quarantine bureau coal inspection technique center,qinhuangdao, China, national key laboratory of metastable materials science and technology,yanshan university,qinhuangdao, China, national key laboratory of metastable materials science and technology,yanshan university,qinhuangdao, China, national key laboratory of metastable materials science and technology,yanshan university,qinhuangdao, China
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Authors
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