Characterization of Polysaccharide by HPLC: Extraction and Anticancer Effects

Cervical cancer is a serious health hazard for women's reproductive system cancer; the method of treatment for cervical cancer is still in surgery,chemotherapy,and radiotherapy as the basic means,but with many complications. the effects of natural medicines for cervical cancer are increasingly becoming the focus of people's attentions. by studying the polysaccharide of cervical cancer in mice,we found that shark cartilage polysaccharide can increase the serum levels of t-sod and gsh and decrease mda level significantly in the tumor mice. the distribution of the drug in the tissue was determined by hplc method; the drug can be drawn in the liver and kidney the highest,followed by the spleen,lung,and brain levels being the lowest. polysaccharide can inhibit tumor growth in the mice which may be connected with the enhanced immunity and the antioxidant capacity. © 2014 liming gao et al.