Physicochemical Analysis and Molecular Modeling of the Fosinopril β -Cyclodextrin Inclusion Complex

This research investigates the interaction between fosinopril sodium (fos) and beta-cyclodextrin (β-cd) in aqueous solution and in solid state,in order to prove the formation of an inclusion complex between the two components. the stoichiometry of the inclusion complex was found as 1: 1 by employing continuous variation method in uv. the formation constant was calculated as 278.93 m-1 using benesi-hildebrand equation. the kneaded product (kp) and the physical mixture (pm) were further experimentally examined,using ftir,powder x-ray diffractometry,and thermal analysis. the results confirm that the physicochemical properties of the fos/β-cd kp are different from fos and that the kneading method leads to formation of solid state inclusion complex between fos and β-cd. structural studies of the fos/β-cd were carried out using molecular modeling techniques,in order to explain the complexation mechanism and the host-guest geometry. © 2014 lucreia udrescu et al.