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Parameter estimation of population pharmacokinetic models with stochastic differential equations: Implementation of an estimation algorithm
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نویسنده
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yan f.-r. ,zhang p. ,liu j.-l. ,tao y.-x. ,lin x. ,lu t. ,lin j.-g.
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منبع
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journal of probability and statistics - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Population pharmacokinetic (ppk) models play a pivotal role in quantitative pharmacology study,which are classically analyzed by nonlinear mixed-effects models based on ordinary differential equations. this paper describes the implementation of sdes in population pharmacokinetic models,where parameters are estimated by a novel approximation of likelihood function. this approximation is constructed by combining the mcmc method used in nonlinear mixed-effects modeling with the extended kalman filter used in sde models. the analysis and simulation results show that the performance of the approximation of likelihood function for mixed-effects sdes model and analysis of population pharmacokinetic data is reliable. the results suggest that the proposed method is feasible for the analysis of population pharmacokinetic data. © 2014 fang-rong yan et al.
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آدرس
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state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university, China, state key laboratory of natural medicines,china pharmaceutical university,nanjing,china,department of mathematics,china pharmaceutical university,nanjing,china,department of mathematics,southeast university, China
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Authors
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