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Possible roles of ectophosphatases in host-parasite interactions
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نویسنده
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gomes m.t. ,lopes a.h. ,meyer-fernandes j.r.
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منبع
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journal of parasitology research - 2011 - دوره : 2011 - شماره : 0
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چکیده
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The interaction and survival of pathogens in hostile environments and in confrontation with host immune responses are important mechanisms for the establishment of infection. ectophosphatases are enzymes localized at the plasma membrane of cells,and their active sites face the external medium rather than the cytoplasm. once activated,these enzymes are able to hydrolyze phosphorylated substrates in the extracellular milieu. several studies demonstrated the presence of surface-located ecto-phosphatases in a vast number of pathogenic organisms,including bacteria,protozoa,and fungi. little is known about the role of ecto-phosphatases in host-pathogen interactions. the present paper provides an overview of recent findings related to the virulence induced by these surface molecules in protozoa and fungi. copyright © 2011 marta t. gomes et al.
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آدرس
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instituto de bioquímica médica,universidade federal do rio de janeiro,ccs,21941-902 rio de janeiro rj,brazil,instituto nacional de cincia e tecnologia de biologia estrutural e bioimagem (inctbeb),ccs,cidade universitária, Brazil, instituto de microbiologia professor paulo de ges,universidade federal do rio de janeiro,ccs, Brazil, instituto de bioquímica médica,universidade federal do rio de janeiro,ccs,21941-902 rio de janeiro rj,brazil,instituto nacional de cincia e tecnologia de biologia estrutural e bioimagem (inctbeb),ccs,cidade universitária, Brazil
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Authors
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