|
|
|
|
Macrofilaricidal activity in Wuchereria bancrofti after 2 weeks treatment with a combination of rifampicin plus doxycycline
|
|
|
|
|
|
|
|
نویسنده
|
hoerauf a. ,debrah a.y. ,mand s. ,marfo-debrekyei y. ,batsa l. ,albers a. ,specht s. ,klarmann u. ,pfarr k. ,adjei o.
|
|
منبع
|
journal of parasitology research - 2011 - دوره : 2011 - شماره : 0
|
|
چکیده
|
Infection with the filarial nematode wuchereria bancrofti can lead to lymphedema,hydrocele,and elephantiasis. since adult worms cause pathology in lymphatic filariasis (lf),it is imperative to discover macrofilaricidal drugs for the treatment of the infection. endosymbiotic wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. in ghana,a pilot study was carried out with 39 lf-infected men; 12 were treated with 200mg doxycycline/day for 4 weeks,16 were treated with a combination of 200mg doxycycline/day + 10mg/kg/day rifampicin for 2 weeks,and 11 patients received placebo. patients were monitored for wolbachia and microfilaria loads,antigenaemia,and filarial dance sign (fds). both 4-week doxycycline and the 2-week combination treatment reduced wolbachia load significantly. at 18 months posttreatment,four-week doxycycline resulted in 100 adult worm loss,and the 2-week combination treatment resulted in a 50 adult worm loss. in conclusion,this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against w. bancrofti. copyright 2011 alexander yaw debrah et al.
|
|
|
|
|
آدرس
|
institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, faculty of allied health sciences,kwame nkrumah university of science and technology,upo,pmb,kumasi,ghana,kumasi centre for collaborative research tropical medicine (kccr),kwame nkrumah university of science and technology,upo,pmb, Ghana, institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, kumasi centre for collaborative research tropical medicine (kccr),kwame nkrumah university of science and technology,upo,pmb, Ghana, kumasi centre for collaborative research tropical medicine (kccr),kwame nkrumah university of science and technology,upo,pmb, Ghana, institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, institute for medical microbiology,immunology and parasitology,university clinic bonn,sigmund-freud-straße 25, Germany, school of medical sciences,kwame nkrumah university of science and technology,upo,pmb, Ghana
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|