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The curative and prophylactic effects of xylopic acid on plasmodium berghei infection in mice
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نویسنده
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boampong j.n. ,ameyaw e.o. ,aboagye b. ,asare k. ,kyei s. ,donfack j.h. ,woode e.
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منبع
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journal of parasitology research - 2013 - دوره : 2013 - شماره : 0
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چکیده
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Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (act) treatments of malaria in ghana. xylopic acid,a pure compound isolated from the fruits of the xylopia aethiopica,was investigated to establish its attributable prophylactic,curative antimalarial,and antipyretic properties. the antimalarial properties were determined by employing xylopic acid (10-100 mg/kg) in icr mice infected with plasmodium berghei. xylopic acid exerted significant (p < 0.05) effects on p. berghei infection similar to artemether/lumefantrine,the standard drug. furthermore,it significantly (p < 0.05) reduced the lipopolysaccharide- (lps-) induced fever in sprague-dawley rats similar to prednisolone. xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent. © 2013 j. n. boampong et al.
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آدرس
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department of biomedical and forensic sciences,university of cape coast, Ghana, department of biomedical and forensic sciences,university of cape coast, Ghana, department of biomedical and forensic sciences,university of cape coast, Ghana, department of biomedical and forensic sciences,university of cape coast, Ghana, department of optometry,school of physical sciences,university of cape coast, Ghana, department of biomedical sciences,faculty of sciences,university of dschang,p.o. box 067, Cameroon, department of pharmacology,faculty of pharmacy and pharmaceutical sciences,college of health sciences, Ghana
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Authors
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