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Genetics of Keratoconus: Where Do We Stand?
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نویسنده
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abu-amero k.k. ,al-muammar a.m. ,kondkar a.a.
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منبع
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journal of ophthalmology - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Keratoconus is a progressive thinning and anterior protrusion of the cornea that results in steepening and distortion of the cornea,altered refractive powers,and reduced vision. keratoconus has a complex multifactorial etiology,with environmental,behavioral,and multiple genetic components contributing to the disease pathophysiology. using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. the review focuses on current knowledge of these genetic risk factors associated with keratoconus. © 2014 khaled k. abu-amero et al.
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آدرس
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ophthalmic genetics laboratory,department of ophthalmology,college of medicine,king saud university,p.o. box 245,riyadh,saudi arabia,glaucoma research char.,department of ophthalmology,college of medicine,king saud university,p.o. box 245,riyadh,saudi arabia,department of ophthalmology,college of medicine,university of florida,jacksonville, United States, ophthalmic genetics laboratory,department of ophthalmology,college of medicine,king saud university,p.o. box 245, Saudi Arabia, ophthalmic genetics laboratory,department of ophthalmology,college of medicine,king saud university,p.o. box 245,riyadh,saudi arabia,glaucoma research char.,department of ophthalmology,college of medicine,king saud university,p.o. box 245, Saudi Arabia
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Authors
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