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Prognostic factors of early morphological response to treatment with ranibizumab in patients with wet age-related macular degeneration
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نویسنده
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chrapek o. ,jarkovský j. ,šín m. ,studnička j. ,kolář p. ,jirková b. ,dušek l. ,pitrová š. ,řehák j.
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منبع
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journal of ophthalmology - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Aim. to assess the significance of age,gender,baseline best corrected visual acuity,baseline macula thickness,and type and size of choroidal neovascularization in early morphological therapeutic response to ranibizumab treatment in patients with the wet form of age-related macular degeneration. methods. from 09/2008 to 06/2013 we evaluated 1153 newly diagnosed,treatment-naïve patients treated with ranibizumab. based on the morphological findings in the macula following the initial 3 injections of ranibizumab,the patients were divided into two groups based on active and inactive choroidal neovascularization. results. after the initial 3 injections of ranibizumab,we examined the sample of 841 eyes with active cnv and 312 eyes with inactive cnv. in the inactive group,we found a statistically higher proportion of occult cnv (p < 0.001) and lower incidence of cnv greater than 5da (p < 0.001) compared with the active group. we found no statistically significant difference in age,gender,baseline best corrected visual acuity,or baseline macula thickness between the inactive and active groups. conclusion. occult cnv and cnv smaller than 5da are optimistic factors for a better morphological therapeutic response at the beginning of ranibizumab treatment. © 2015 oldřich chrapek et al.
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آدرس
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department of ophthalmology,faculty of medicine and dentistry,palacky university,i. p. pavlova 6, Czech Republic, institute of biostatistics and analyses,faculty of medicine and faculty of science,masaryk university,kamenice 126/3, Czech Republic, department of ophthalmology,faculty of medicine and dentistry,palacky university,i. p. pavlova 6, Czech Republic, department of ophthalmology,charles university in prague,university hospital in hradec králové,sokolská 581, Czech Republic, department of ophthalmology,university hospital,jihlavská 340/20, Czech Republic, department of ophthalmology,faculty of medicine and dentistry,palacky university,i. p. pavlova 6, Czech Republic, institute of biostatistics and analyses,faculty of medicine and faculty of science,masaryk university,kamenice 126/3, Czech Republic, private eye clinic,v hůrkách 1296/10, Czech Republic, department of ophthalmology,faculty of medicine and dentistry,palacky university,i. p. pavlova 6, Czech Republic
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Authors
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