Efficacy and acceptability of orthokeratology for slowing myopic progression in children: A systematic review and meta-Analysis

Background. to evaluate the efficacy and acceptability of orthokeratology for slowing myopic progression in children with a well conducted evidence-based analysis. design. meta-analysis. participants. children from previously reported comparative studies were treated by orthokeratology versus control. methods. a systematic literature retrieval was conducted in medline,embase,cochrane library,world health organization international clinical trials registry platform,and clinicaltrials.gov. the included studies were subjected to meta-analysis using stata version 10.1. main outcome measures. axial length change (efficacy) and dropout rates (acceptability) during 2-year follow-up. results. eight studies involving 769 subjects were included. at 2-year follow-up,a statistically significant difference was observed in axial length change between the orthokeratology and control groups,with a weighted mean difference (wmd) of -0.25 mm (95% ci,-0.30 to -0.21). the pooled myopic control rate declined with time,with 55,51,51,and 41% obtained after 6,12,18,and 24 months of treatment,respectively. no statistically significant difference was obtained for dropout rates between the orthokeratology and control groups at 2-year follow-up (or,0.79; 95% ci,0.52 to 1.22). conclusions. orthokeratology is effective and acceptable for slowing myopic progression in children with careful education and monitoring. © 2015 daizong wen et al.