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First attempt to implement ophthalmia neonatorum prophylaxis in Angola: Microorganisms,efficacy,and obstacles
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نویسنده
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alexandre i. ,justel m. ,martinez p. ,ortiz de lejarazu r. ,pastor j.c.
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منبع
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journal of ophthalmology - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Purpose. to determine the efficacy of povidone-iodine (p-i) prophylaxis for ophthalmia neonatorum (on) in angola and to document maternal prevalence and mother-to-child transmission rates. methods. endocervical samples from mothers n = 317 and newborn conjunctival smears n = 245 were analysed by multiplex polymerase chain reaction (pcr) for chlamydia trachomatis (ct),neisseria gonorrhoeae (ng),and mycoplasma genitalium (mg). newborns were randomized into a noninterventional group and an interventional group that received a drop of p-i 2.5% bilaterally after conjunctival smear collection. mothers were trained to identify signs of on and attend a follow-up visit. results. forty-two newborns had ocular pathology,and 11 (4.4%) had clinical signs of on at the time of delivery. maternal pcr was positive for mg n = 19,ct n = 8,and ng n = 2. six newborns were positive for ct n = 4,mg n = 2,and ng n = 1. mother-to-child transmission rates were 50% for ct and ng and 10.5% for mg. only 16 newborns returned for follow-up. conclusions. lack of maternal compliance prevented successful testing of prophylactic p-i efficacy in on prevention. nevertheless,we documented the prevalence and mother-to-child transmission rates for ct,ng,and mg. these results emphasize the need to develop an effective angolan educational and prophylactic on program. © 2015 isabel alexandre et al.
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آدرس
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iona,eye institute,rua de olivencą, Angola, department of microbiology and immunology,hospital clinico universitario,avenida ramon y cajal 3, Spain, ioba,eye institute,university of valladolid,paseo de belen 17, Spain, department of microbiology and immunology,hospital clinico universitario,avenida ramon y cajal 3, Spain, ioba,eye institute,university of valladolid,paseo de belen 17, Spain
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Authors
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