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Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats
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نویسنده
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kanamoto t. ,souchelnytskyi n. ,kurimoto t. ,ikeda y. ,sakaue h. ,munemasa y. ,kiuchi y.
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منبع
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journal of ophthalmology - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Background. to investigate how transcorneal electric stimulation (tes) affects the retina,by identifying those proteins up-and downregulated by transcorneal electric stimulation (tes) in the retina of rats. methods. adult wistar rats received tes on the left eyes at different electrical currents while the right eyes received no treatment and served as controls. after tes,the eye was enucleated and the retina was isolated. the retinas were analyzed by proteomics. results. proteomics showed that twenty-five proteins were upregulated by tes. the identified proteins included cellular signaling proteins,proteins associated with neuronal transmission,metabolic proteins,immunological factors,and structural proteins. conclusions. tes induced changes in expression of various functional proteins in the retina. © 2015 takashi kanamoto et al.
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آدرس
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department of ophtahlomology,hiroshima memorial hospital,1-4-3 honkawacho,minami-ku, Japan, personalized cancer medicine unit,department of oncology-pathology,karolinska institute, Sweden, department of ophthalmology,osaka medical college,2-7 daigaku-cho,takatsuki-shi, Japan, department of ophthalmology,kyushu university,3-1-1 maedashi,higashi-ku, Japan, department of pharmaceutical sciences,international university of health and welfare,2600-1 kitakanemaru,tahara-shi, Japan, department of ophthalmology,st. marianna medical college,2-16-1 sugao,miyamae-ku,kawasaki-shi, Japan, department of ophthalmology and visual sciences,hiroshima university,1-2-3 kasumi,minami-ku, Japan
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Authors
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