Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters

Background. optical coherence tomography (oct) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. the aim of this study is to analyze associations of central corneal thickness (cct) as measured by oct with ocular and systemic cardiovascular parameters. methods. a cross-sectional study of 734 persons was performed in a working age population. only healthy eyes were included. a comprehensive ophthalmological examination including refraction,noncontact tonometry,and imaging of the anterior segment by sd-oct was performed. in parallel,a broad range of systemic cardiovascular parameters were measured. associations were analyzed using a generalized estimating equations' model. results. cct measurements showed a significant association with corneal curvature and intraocular pressure: a thinner cct was associated with a flatter cornea and with lower intraocular pressure (p < 0.001). age was positively associated with cct (p < 0.001); all other cardiovascular parameters were not associated. conclusion. a thinner cornea is associated with a flatter surface and with lower intraocular pressure readings,while there are no independent associations with refraction and systemic cardiovascular parameters. our findings highlight the value of sd-oct cct measurements as a standard tool in anterior segment analysis. � 2016 alexander karl-georg schuster et al.