Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series

Purpose. to evaluate daily spectral-domain optical coherence tomography (sd-oct) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (amd) treated with intravitreous bevacizumab (1.25 mg),during a 30-day follow-up period. methods. in prospective,interventional study,sd-oct was performed daily for 30 days after the first intravitreal injection. the baseline,initial-decrease,minimal,and final central retinal thicknesses (crts) were assessed. results. nine eyes of nine patients with neovascular amd were enrolled. the mean baseline crt was 625.3±182.5 μm,and the mean final crt was 383.4±163.0 μm (mean difference,206.1±167.6 μm),a difference that reached significance (p=0.006). after the first injection,the initial decrease in the crt was seen as an average of one day after injection (mean crt,503.6±189.10 μm; p=0.0431). the speed of the reduction in the crt tended to decrease by day 17. the mean crt was 336.5±105.44 μm and the mean minimal crt on day 30 was 320.75±96.38 μm. conclusion. the crt decreased early after the first injection. we observed a tendency for reductions in the speed with which the crt decreased by day 17 after the first injection,which may affect retreatment regime. © 2016 eduardo a. novais et al.