Causative microorganisms of infectious endophthalmitis: A 5-year retrospective study

This study aimed to identify the microbial etiology of infectious endophthalmitis and to determine the antibacterial susceptibilities of bacterial isolates at an eye hospital in south china. a retrospective analysis was carried out on 330 patients with clinically diagnosed infectious endophthalmitis who underwent microbiological evaluation from january 2010 to december 2014. of the 330 patients,193 patients (58.5%) had posttraumatic endophthalmitis,67 patients (20.3%) had postoperative endophthalmitis,61 patients (18.5%) had endogenous endophthalmitis,and 9 patients (2.7%) had postcorneal infective endophthalmitis. of the 105 cases (31.8%) of culture-positive endophthalmitis,79 cases (75.2%) had bacterial growth and 26 cases (24.8%) had fungal growth. in posttraumatic endophthalmitis,gram-positive bacteria were the predominant species,followed by gram-negative bacteria and fungi. in endogenous endophthalmitis,gram-negative bacteria were the predominant species,followed by fungi and gram-positive bacteria. in postsurgical endophthalmitis,all infections were bacterial. however,in postcorneal infective endophthalmitis,all infections were fungal. overall,levofloxacin showed the highest activity against bacterial isolates. there was a significant difference in the susceptibility to tobramycin between the isolates from posttraumatic and postoperative endophthalmitis (p < 0.05). the results of this study identify the microbial spectrum of infectious endophthalmitis in this clinical setting. © 2016 fang duan et al.