Effectiveness and Optical Quality of Topical 3.0% Diquafosol versus 0.05% Cyclosporine A in Dry Eye Patients following Cataract Surgery

Purpose. to evaluate the effectiveness and optical quality of 3.0% topical diquafosol versus 0.05% cyclosporine a in dry eye patients following cataract surgery. methods. in total,40 eyes of 40 patients newly diagnosed with dry eye syndrome 1 week after cataract surgery were randomized to receive either 3.0% diquafosol ophthalmic solution six times daily or 0.05% cyclosporine a twice daily for 3 months. outcome measures were tear film break-up time (tbut),results on schirmer 1 test,ocular surface staining score,the ocular surface disease index (osdi) score,and higher-order aberrations (hoas). measurements were taken at baseline and at 1,2,and 3 months. results. in the diquafosol group,tbut showed higher outcomes than the cyclosporine a group at 1 and 3 months. both groups showed increased scores on schirmer 1 test. the ocular surface staining score decreased in all periods in both groups. vertical coma and total hoas decreased more in the cyclosporine a group than in the diquafosol group at 3 months. conclusion. both 3.0% diquafosol and 0.05% cyclosporine a were effective in treating dry eye after cataract surgery. diquafosol was more effective in increasing the tear secretion,but cyclosporine a was more effective in improving optical aberrations. copyright © 2016 jang hoon lee et al.