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Nonlethal Levels of Zeaxanthin Inhibit Cell Migration,Invasion,and Secretion of MMP-2 via NF- κ B Pathway in Cultured Human Uveal Melanoma Cells
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نویسنده
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bi m.-c. ,hose n. ,xu c.-l. ,zhang c. ,sassoon j. ,song e.
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منبع
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journal of ophthalmology - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Zeaxanthin at nonlethal dosages (3-10 μm) significantly inhibited the cell migration of cultured uveal melanoma cells (c918 cell line) as determined by wound healing assay and boyden chamber assay. matrigel invasion assay showed that cell invasion of uveal melanoma cells could be significantly inhibited by zeaxanthin. secretion of mmp-2 by melanoma cells was significantly inhibited by zeaxanthin in a dose-dependent manner as measured by elisa kit. zeaxanthin also significantly inhibited the nf-κb levels in nuclear extracts of the um cells,which is the upstream of the mmp-2 secretion. these results suggest that zeaxanthin might be a potentially therapeutic approach in the prevention of metastasis in uveal melanoma. copyright © 2016 ming-chao bi et al.
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آدرس
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department of ophthalmology,first hospital of jilin university,changchun,china,tissue culture center,new york eye and ear infirmary of mount sinai,new york,ny, United States, fordham university,new york,ny, United States, department of ophthalmology,first hospital of jilin university,changchun, China, shanghai tenth people's hospital,tongji university school of medicine,shanghai, China, tissue culture center,new york eye and ear infirmary of mount sinai,new york,ny, United States, department of ophthalmology,first hospital of jilin university,changchun,china,lixiang eye hospital,soochow university,suzhou, China
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Authors
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