Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

Purpose. to further investigate the pathogenesis of late-onset capsular block syndrome (cbs) and to evaluate the safety of surgical treatment. methods. seven patients diagnosed with late-onset cbs were retrospectively analyzed. anterior chamber depth (acd),intraocular pressure (iop),refractive diopter,and best-corrected visual acuity (bcva) before and after surgery were recorded. the opaque substance was tested with western blot,and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor,respectively. results. patients who had undergone surgical treatment showed a significant bcva and spherical equivalent refractive error improvement (p=0.002,p=0.021,resp.). nevertheless,acd and iop before and after surgery were in normal range with no difference (p=0.165,p=0.749,resp.). αb-crystallin and βb-crystallin were detected in all opaque substances. tumor necrosis factor-alpha (tnf-α) and interlukin-1β (il-1β) levels in opaque substance were significantly higher than those in aqueous humor (p=0.038,p=0.007,resp.),while il-2 and il-6 were not detected in any samples. conclusions. opaque substance is derived from human lens epithelial cells. inflammatory cytokines may be involved in the pathogenesis of late-onset cbs. in addition,surgical treatment is an effective approach. this trial is registered with chictr-ior-17011287. © 2017 yang huang et al.