Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis

The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (poag) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-fu-) soaked amniotic membranes for the treatment of poag patients. among them,30 patients (41 eyes) were treated with trabeculectomy in combination with 5-fu-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with mmc. preoperative and postoperative intraocular pressures (iop),cup/disc ratio,visual acuity and postoperative macular oct,complications,treatment,and number of corneal endothelial cells were measured,recorded,and analyzed. at the end of 2 years of follow-up,iop of 36 (87.8%) eyes of patients in the 5-fu group and iop of 28 (80%) eyes of patients in the mmc group were ≤21 mmhg and patients in the 5-fu group had more stable iop than patients in the mmc group. during the two years of follow-up,the visual acuity of 22 (53.7%) eyes in the 5-fu group remained unchanged or even improved. trabeculectomy in combination with 5-fu-soaked biological amniotic membranes can be a surgical option for poag patients. © 2017 chenming zhang et al.