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Switch to Aflibercept in the Treatment of Neovascular AMD: Long-Term Results
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نویسنده
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neves cardoso p. ,pinheiro a.f. ,meira j. ,pedrosa a.c. ,falcão m.s. ,pinheiro-costa j. ,falcão-reis f. ,carneiro â.m.
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منبع
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journal of ophthalmology - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Purpose. to report the long-term clinical outcomes after switching from intravitreal bevacizumab or ranibizumab to aflibercept therapy in eyes with amd. methods. retrospective analysis of changes in bcva,sd-oct image,and frequency of injections after 1,2,and 3 years of follow-up. results. 164 eyes were analyzed,101 eyes switched from bevacizumab (group 1) and 63 from ranibizumab (group 2). one year after the switch,there was an overall nonsignificant mean decrease of 2 etdrs letters in bcva. three years after,there was an overall mean decrease of 7 etdrs letters,which was statistically significant. a significant improvement in the mean crt was found at 1,2,and 3 years. there was a significant decrease in the mean number of injections per year (7.8 to 6.5,p<0.005) between the first and third year. conclusion. aflibercept can be useful in the management of refractory neovascular amd,with a good morphological response. however,in the long-term,bcva stabilization was not achieved. © 2017 pedro neves cardoso et al.
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آدرس
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department of ophthalmology,centro hospitalar de são joão,university of porto,porto, Portugal, faculty of medicine,university of porto,porto, Portugal, department of ophthalmology,centro hospitalar de são joão,university of porto,porto, Portugal, department of ophthalmology,centro hospitalar de são joão,university of porto,porto, Portugal, faculty of medicine,university of porto,porto,portugal,departments of surgery and physiology,faculty of medicine,university of porto,porto, Portugal, department of ophthalmology,centro hospitalar de são joão,university of porto,porto,portugal,department of anatomy,university of porto,porto, Portugal, department of ophthalmology,centro hospitalar de são joão,university of porto,porto,portugal,departments of surgery and physiology,faculty of medicine,university of porto,porto, Portugal, department of ophthalmology,centro hospitalar de são joão,university of porto,porto,portugal,departments of surgery and physiology,faculty of medicine,university of porto,porto, Portugal
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Authors
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