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Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry
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نویسنده
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frost s. ,robinson l. ,rowe c.c. ,ames d. ,masters c.l. ,taddei k. ,rainey-smith s.r. ,martins r.n. ,kanagasingam y.
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منبع
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journal of ophthalmology - 2017 - دوره : 2017 - شماره : 0
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چکیده
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Cortical cholinergic deficiency is prominent in alzheimer's disease (ad),and published findings of diminished pupil flash response in ad suggest that this deficiency may extend to the visual cortical areas and anterior eye. pupillometry is a low-cost,noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. the aim of the study was to evaluate pupillometry for early detection of ad by comparing the pupil flash response (pfr) in ad (n=14) and cognitively normal healthy control (hc,n=115) participants,with the hc group stratified according to high (n=38) and low (n=77) neocortical amyloid burden (nab). constriction phase pfr parameters were significantly reduced in ad compared to hc (maximum acceleration p<0.05,maximum velocity p<0.0005,average velocity p<0.005,and constriction amplitude p<0.00005). the high-nab hc subgroup had reduced pfr response cross-sectionally,and also a greater decline longitudinally,compared to the low-nab subgroup,suggesting changes to pupil response in preclinical ad. the results suggest that pfr changes may occur in the preclinical phase of ad. hence,pupillometry has a potential as an adjunct for noninvasive,cost-effective screening for preclinical ad. © 2017 shaun frost et al.
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آدرس
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commonwealth scientific and industrial research organisation (csiro),perth,wa,australia,australian e-health research centre,perth,wa, Australia, commonwealth scientific and industrial research organisation (csiro),perth,wa,australia,australian e-health research centre,perth,wa, Australia, department of nuclear medicine,centre for pet,austin health,melbourne,vic, Australia, department of psychiatry,university of melbourne,melbourne,vic,australia,mental health research institute (mhri),university of melbourne,melbourne,vic,australia,national ageing research institute,melbourne,vic, Australia, mental health research institute (mhri),university of melbourne,melbourne,vic, Australia, school of medical and health sciences,edith cowan university,joondalup,wa, Australia, school of medical and health sciences,edith cowan university,joondalup,wa,australia,sir james mccusker alzheimer's disease research unit,hollywood private hospital,perth,wa, Australia, school of medical and health sciences,edith cowan university,joondalup,wa,australia,sir james mccusker alzheimer's disease research unit,hollywood private hospital,perth,wa,australia,school of biomedical sciences,macquarie university,north ryde,nsw,australia,school of psychiatry and clinical neurosciences,university of western australia,crawley,wa, Australia, commonwealth scientific and industrial research organisation (csiro),perth,wa,australia,australian e-health research centre,perth,wa, Australia
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Authors
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