Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy

Galectin-1 (gal-1) has been proved to be an important factor in the process of tumor angiogenesis recently. as a small molecule,otx008 serves as a selective inhibitor of gal-1. in this study,the role of gal-1 and the antiangiogenic effect of otx008 on retinal neovascularization (rnv) were investigated using a mouse model of oxygen-induced retinopathy. the outcome indicated that gal-1 was overexpressed and closely related to retinal neovessels in oir. after intravitreal injection of otx008 at p12,the rnv was significantly reduced at p17,measuring by cross-sectional h&e staining and whole-mount fluorescence. our results demonstrate the inhibitory function of otx008 on rnv,which provides a promising strategy of treating retinal angiogenic diseases such as retinopathy of prematurity and proliferative diabetic retinopathy. © 2017 ning yang et al.