Factors Contributing to Long-Term Severe Visual Impairment in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Purpose. to study the correlation between demographics and clinical variables and long-term severe visual impairment in patients with stevens-johnson syndrome (sjs) or toxic epidermal necrolysis (ten). methods. a retrospective chart review of sjs/ten patients between 2004 and 2014 was conducted. demographics,causative agents,ocular manifestations,and visual outcomes were collected. the data were analyzed using a multivariate logistic regression model. results. of the 89 patients including sjs (65,73.03%),ten (15,16.85%),and sjs-ten overlap (9,10.11%),55 were female. the mean age was 41.58 ± 19.17 years. the most common identified agents were medications. among these groups,antibiotics were the most prevalent (47.19%). three patients (3.7%) had unknown etiology. antibiotics and nonpharmaceutical triggers were significantly associated with long-term severe visual impairment (odds ratio 4.32; p=0.015 and 7.20; p=0.037,resp.). there was a significant negative relationship between hiv infection and long-term severe visual impairment (p=0.021). among all chronic ocular complications,only corneal neovascularization significantly correlated with severe visual impairment (p=0.001). conclusions. sjs/ten patients caused by nonpharmaceutical triggers or antibiotics have an increased risk of developing long-term severe visual impairment from corneal neovascularization. hiv infection might be a protective factor against long-term poor visual outcomes. © 2017 passara jongkhajornpong et al.