Intrahepatic sarcomatoid cholangiocarcinoma

Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. we report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. the patient had early onset disease recurrence within 5 weeks of surgery. here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. the patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery. © 2010 shalini malhotra et al.