Cancer malignancy is enhanced by glyceraldehyde-derived advanced glycation end-products

The receptor for advanced glycation end-products (rages) is associated with the malignancy of cancer. a recent study has suggested that glyceraldehyde-derived ages (glycer-ages) enhanced the malignancy of melanoma cells,but glucose-derived ages did not. however,the effects of glycer-ages on other cancer cells remain poorly understood,and the molecular mechanisms behind the above-mentioned effect have not been clarified. the present paper aimed to examine the effect of glycer-ages on cultured lung cancer a549 cells. rage was expressed in a549 cells. glycer-ages significantly attenuated cell proliferation. furthermore,glycer-ages enhanced the migration capacity of the cells by activating rac1 via ros and also increased their invasion capacity. we demonstrated that glycer-ages enhanced the migration and invasion of a549 cells rather than their proliferation. these results suggest that glycer-ages play a critical role in the malignancy of cancer rather than its proliferation and are potential targets for therapeutic intervention. copyright © 2010 jun-ichi takino et al.