|
|
|
|
Bmi-1 regulates snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells
|
|
|
|
|
|
|
|
نویسنده
|
chiou s.h. ,yu c.-c. ,lo w.-l. ,chen y.-w. ,huang p.-i. ,hsu h.-s. ,tseng l.-m. ,hung s.-c. ,kao s.-y. ,chang c.-j.
|
|
منبع
|
journal of oncology - 2011 - دوره : 2011 - شماره : 0
|
|
چکیده
|
Recent studies suggest that aldh1 is a putative marker for hnscc-derived cancer stem cells. however,the regulation mechanisms that maintain the stemness and metastatic capability of hnscc- aldh 1 + cells remain unclear. initially,hnscc- aldh 1 + cells from hnscc patient showed cancer stemness properties,and high expression of bmi1 and snail. functionally,tumorigenic properties of hnscc- aldh 1 + cells could be downregulated by knockdown of bmi-1. overexpression of bmi-1 altered in expression property aldh 1 - cells to that of aldh 1 + cells. furthermore,knockdown of bmi-1 enhanced the radiosensitivity of radiation-treated hnscc- aldh 1 + cells. moreover,overexpression of bmi-1 in hnscc- aldh 1 - cells increased tumor volume and number of pulmonary metastatic lesions by xenotransplant assay. importantly,knock-down of bmi1 in hnscc- aldh 1 + cells significantly decreased distant metastases in the lungs. clinically,coexpression of bmi-1/snail/aldh1 predicted the worst prognosis in hnscc patients. collectively,our data suggested that bmi-1 plays a key role in regulating snail expression and cancer stemness properties of hnscc- aldh 1 + cells. copyright © 2011 cheng-chia yu et al.
|
|
|
|
|
آدرس
|
department of medical research and education,taipei veterans general hospital,taipei 11217,taiwan,department of surgery,taipei veterans general hospital, Taiwan, institute of oral biology and biomaterial science,chung-shan medical university,taichung 40201,taiwan,department of dentistry,chung shan medical university hospital, Taiwan, division of oral and maxillofacial surgery,department of stomatology,taipei veterans general hospital, Taiwan, department of medical research and education,taipei veterans general hospital, Taiwan, department of medical research and education,taipei veterans general hospital,taipei 11217,taiwan,department of surgery,taipei veterans general hospital, Taiwan, institute of clinical medicine,national yang-ming university, Taiwan, institute of clinical medicine,national yang-ming university, Taiwan, department of medical research and education,taipei veterans general hospital,taipei 11217,taiwan,department of surgery,taipei veterans general hospital, Taiwan, division of oral and maxillofacial surgery,department of stomatology,taipei veterans general hospital, Taiwan, department of pharmacy practice,tri-service general hospital,114 national defense medical center, Taiwan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|