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Cancer stem cells in head and neck squamous cell carcinoma
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نویسنده
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wong m.h. ,monroe m.m. ,anderson e.c. ,clayburgh d.r.
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منبع
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journal of oncology - 2011 - دوره : 2011 - شماره : 0
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چکیده
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Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells,termed cancer stem cells (cscs),whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. in head and neck squamous cell carcinoma (hnscc),as with other malignancies,cancer stem cells have been increasingly shown to have an integral role in tumor initiation,disease progression,metastasis and treatment resistance. in this paper we summarize the current knowledge of the role of cscs in hnscc and discuss the therapeutic implications and future directions of this field. copyright © 2011 marcus m. monroe et al.
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آدرس
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department of dermatology,cell and developmental biology,knight cancer institute,oregon health and science university,3181 sw sam jackson park rd,portland, United States, department of otolaryngologyhead and neck surgery,oregon health and science university,3181 sw sam jackson park rd,portland, United States, division of hematology and medical oncology,oregon health and science university,3181 sw sam jackson park rd,portland, United States, department of otolaryngologyhead and neck surgery,oregon health and science university,3181 sw sam jackson park rd,portland, United States
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Authors
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