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Hypermethylation of CCND2 may reflect a smoking-induced precancerous change in the lung
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نویسنده
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vesselle h. ,salskov a. ,hawes s.e. ,stern j.e. ,feng q. ,jordan c.d. ,wiens l. ,rasey j. ,lu h. ,kiviat n.b.
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منبع
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journal of oncology - 2011 - دوره : 2011 - شماره : 0
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چکیده
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It remains unknown whether tobacco smoke induces dna hypermethylation as an early event in carcinogenesis or as a late event,specific to overt cancer tissue. using methylight assays,we analyzed 316 lung tissue samples from 151 cancer-free subjects (121 ever-smokers and 30 never-smokers) for hypermethylation of 19 genes previously observed to be hypermethylated in nonsmall cell lung cancers. only apc (39),ccnd2 (21),cdh1 (7),and rarb (4) were hypermethylated in >2 of these cancer-free subjects. ccnd2 was hypermethylated more frequently in ever-smokers (26) than in never-smokers (3). ccnd2 hypermethylation was also associated with increased age and upper lobe sample location. apc was frequently hypermethylated in both ever-smokers (41) and never-smokers (30). bves,cdh13,cdkn2a (p16),cdkn2b,dapk1,igfbp3,igsf4,kcnh5,kcnh8,mgmt,opcml,pcsk6,rassf1,runx,and tms1 were rarely hypermethylated (<2) in all subjects. hypermethylation of ccnd2 may reflect a smoking-induced precancerous change in the lung. copyright © 2011 alexander salskov et al.
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آدرس
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department of radiology,school of medicine,university of washington,seattle, United States, department of radiology,school of medicine,university of washington,seattle, United States, department of epidemiology,school of public health,university of washington,seattle, United States, department of pathology,school of medicine,university of washington,seattle, United States, department of pathology,school of medicine,university of washington,seattle, United States, department of pathology,school of medicine,university of washington,seattle, United States, department of radiology,school of medicine,university of washington,seattle, United States, department of radiation oncology,school of medicine,university of washington,seattle, United States, department of pathology,school of medicine,university of washington,seattle, United States, department of pathology,school of medicine,university of washington,seattle, United States
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Authors
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