|
|
|
|
Vascular disrupting agent arsenic trioxide enhances thermoradiotherapy of solid tumors
|
|
|
|
|
|
|
|
نویسنده
|
griffin r.j. ,williams b.w. ,koonce n.a. ,bischof j.c. ,song c.w. ,asur r. ,upreti m.
|
|
منبع
|
journal of oncology - 2012 - دوره : 2012 - شماره : 0
|
|
چکیده
|
Our previous studies demonstrated arsenic trioxide- (ato-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors. these results suggested that a trimodality approach of radiation,ato,and local hyperthermia may have potent therapeutic efficacy against solid tumors. here,we report the antitumor effect of hypofractionated radiation followed by ato administration and local 42.5°c hyperthermia and the effects of cisplatin and thermoradiotherapy. we found that the therapeutic efficacy of ato-based thermoradiotherapy was equal or greater than that of cisplatin-based thermoradiotherapy,and marked evidence of in vivo apoptosis and tumor necrosis were observed in ato-treated tumors. we conclude that ato-based thermoradiotherapy is a powerful means to control tumor growth by using vascular disruption to augment the effects of thermal and radiation therapy. copyright © 2012 robert j. griffin et al.
|
|
|
|
|
آدرس
|
department of radiation oncology,university of arkansas for medical sciences,4301 w. markham street,little rock, United States, department of mechanical engineering and therapeutic radiology,university of minnesota,240 delaware street,minneapolis, United States, department of radiation oncology,university of arkansas for medical sciences,4301 w. markham street,little rock, United States, department of mechanical engineering and therapeutic radiology,university of minnesota,240 delaware street,minneapolis, United States, department of mechanical engineering and therapeutic radiology,university of minnesota,240 delaware street,minneapolis, United States, department of radiation oncology,university of arkansas for medical sciences,4301 w. markham street,little rock, United States, department of radiation oncology,university of arkansas for medical sciences,4301 w. markham street,little rock, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|