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   Molecular analysis of TTF-1 and TTF-2 genes in patients with early onset papillary thyroid carcinoma  
   
نویسنده espadinha c. ,silva a.l. ,cabrera r. ,bugalho m.j.
منبع journal of oncology - 2012 - دوره : 2012 - شماره : 0
چکیده    Two common variants,close from ttf-1 and ttf-2,were shown to predispose to thyroid cancer (tc) in european populations. we aimed to investigate whether ttf-1 and ttf-2 variants might contribute to tc early onset (eo). tumor samples from eighteen patients with papillary tc (ptc),who underwent total thyroidectomy at an age of ≤21,were screened for ttf-1 and ttf-2 variants. no ttf-1 variants were documented; two novel germinal ttf-2 variants,c.200cg (p.a67g) and c.510ca (p.a170a),were identified in two patients. two already described ttf-2 variants were also documented; the allelic frequency among patients was not different from that observed among controls. moreover,ret/ptc rearrangements and the brafv600e mutation were identified in 5/18 and 2/18 ptcs,respectively. thyroglobulin (tg) and thyroid peroxidase (tpo) expression was found to be significantly decreased in tumors,and the lowest level of tpo expression occurred in a tumor harboring both the p.a67gttf-2 variant and a ret/ptc3 rearrangement. copyright 2012 carla espadinha et al.
آدرس centro de investigação de patobiologia molecular,instituto português de oncologia de lisboa francisco gentil e.p.e., Portugal, centro de investigação de patobiologia molecular,instituto português de oncologia de lisboa francisco gentil e.p.e., Portugal, serviço de anatomia patológica,instituto português de oncologia de lisboa francisco gentil e.p.e., Portugal, centro de investigação de patobiologia molecular,instituto português de oncologia de lisboa francisco gentil e.p.e.,1099-023 lisboa,portugal,serviço de endocrinologia,instituto português de oncologia de lisboa francisco gentil e.p.e.,1099-023 lisboa,portugal,clnica universitria de endocrinologia,faculdade de ciências médicas,universidade nova de lisboa, Portugal
 
     
   
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