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Methylation-mediated molecular dysregulation in clinical oral malignancy
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نویسنده
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towle r. ,garnis c.
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منبع
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journal of oncology - 2012 - دوره : 2012 - شماره : 0
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چکیده
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Herein we provide a concise review of the state of methylation research as it pertains to clinical oral cancerous and precancerous tissues. we provide context for ongoing research efforts in this field and describe technologies that are presently being applied to analyze clinical specimens. we also discuss the various recurrent methylation changes that have been reported for oral malignancy (including those genes frequently silenced by promoter methylation and the small rnas with activity modulated by methylation changes) and describe surrogate disease markers identified via epigenetic analysis of saliva and blood specimens from patients with oral cancer. copyright © 2012 rebecca towle and cathie garnis.
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آدرس
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department of integrative oncology,british columbia cancer research centre,675 west 10th avenue,vancouver, Canada, department of integrative oncology,british columbia cancer research centre,675 west 10th avenue,vancouver,bc v5z 1l3,canada,department of surgery,faculty of medicine,university of british columbia,910 west 10th avenue,vancouver, Canada
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Authors
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