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Survival advantage associated with decrease in stage at detection from stage IIIC to stage IIIA epithelial ovarian cancer
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نویسنده
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hoff j. ,baldwin l. ,lefringhouse j. ,pavlik e. ,miller r. ,desimone c. ,ueland f. ,tucker t. ,kryscio r. ,van nagell j.r.
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منبع
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journal of oncology - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Objective. the aim of this study was to document the survival advantage of lowering stage at detection from stage iiic to stage iiia epithelial ovarian cancer. methods. treatment outcomes and survival were evaluated in patients with stage iiia and stage iiic epithelial ovarian cancer treated from 2000 to 2009 at the university of kentucky markey cancer center (ukmcc) and seer institutions. results. cytoreduction to no visible disease (p<0.0001) and complete response to platinum-based chemotherapy (p<0.025) occurred more frequently in stage iiia than in stage iiic cases. time to progression was shorter in patients with stage iiic ovarian cancer (17±1 months) than in those with stage ii1a disease (36±8 months). five-year overall survival (os) improved from 41% in stage iiic patients to 60% in stage iiia patients treated at ukmcc and from 37% to 56% in patients treated at seer institutions for a survival advantage of 19% in both data sets. 53% of stage iiia and 14% of stage iiic patients had ned at last followup. conclusions. decreasing stage at detection from stage iiic to stage iiia epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor cytoreduction and platinum-based chemotherapy. © 2014 john hoff et al.
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آدرس
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division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States, cancer prevention and control program,markey cancer center,university of kentucky,lexington, United States, department of statistics,markey cancer center,university of kentucky,lexington, United States, division of gynecologic oncology,department of obstetrics and gynecology,markey cancer center,university of kentucky,800 rose street,lexington, United States
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Authors
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