|
|
Primary circulating prostate cells are not detected in men with low grade small volume prostate cancer
|
|
|
|
|
نویسنده
|
murray n.p. ,reyes e. ,fuentealba c. ,orellana n. ,jacob o.
|
منبع
|
journal of oncology - 2014 - دوره : 2014 - شماره : 0
|
چکیده
|
Objective. to determine if primary circulating prostate cells (cpcs) are found in all men with prostate cancer. methods and patients. a prospective study,to analyze all men with an elevated psa between 4.0 and 10.0 ng/ml undergoing initial biopsy. primary cpcs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-psa; positive samples underwent a second process with anti-p504s. a malignant primary cpc was defined as psa (+) p504s (+) and a test positive if 1 cell/4 ml was detected. biopsy results were registered as cancer/no-cancer,number of cores positive,and percent infiltration of the cores. results. 328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy,and 42/328 (12.8%) were negative for primary cpcs. cpc negative men were significantly older,and had lower psa levels,lower gleason scores,and fewer positive cores and with infiltration by the cancer. 38/42 (91%) of cpc negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of cpc positive men. conclusions. using primary cpc detection as a sequential test to select men with an elevated psa for biopsy,the risk of missing clinically significant prostate cancer is minimal when the patient is primary cpc negative; less than 0.5% of all primary cpc negative men had a clinically significant prostate cancer. © 2014 nigel p. murray et al.
|
|
|
آدرس
|
hospital carabineros of chile,nunoa,santiago,chile,circulating tumor cell unit,faculty of medicine,university mayor,las condes,santiago,chile,institute of bio-oncology,providencia, Chile, hospital carabineros of chile,nunoa,santiago,chile,faculty of medicine,diego portales university,manuel rodríguez sur 415, Chile, hospital carabineros of chile,nunoa, Chile, hospital carabineros of chile,nunoa, Chile, hospital carabineros of chile,nunoa, Chile
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|