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Prognostic impact of hypoxia-inducible miRNA-210 in patients with lung adenocarcinoma
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نویسنده
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osugi j. ,kimura y. ,owada y. ,inoue t. ,watanabe y. ,yamaura t. ,fukuhara m. ,muto s. ,okabe n. ,matsumura y. ,hasegawa t. ,yonechi a. ,hoshino m. ,higuchi m. ,shio y. ,suzuki h. ,gotoh m.
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منبع
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journal of oncology - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Objective. the aim of this study was to investigate the prognostic value of microrna-210 (mir-210) expression in patients with non-small-cell lung cancer (nsclc). methods. we examined the mir-210 expression of samples of 80 patients,who underwent surgical resection at fukushima medical university from 2004 to 2007,by using quantitative rt-pcr. the relationship between mir-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. results. mir-210 expression showed an inverse correlation with disease-free and overall survival in patients with nsclc. significant correlations were found between mir-210 expression and lymph node metastasis,late disease stages,and poor prognosis in patients with adenocarcinoma. multivariate cox analysis indicated that mir-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. conclusions. we showed that mir-210 may be a prognostic biomarker for patients with nsclc,especially for those with lung adenocarcinoma. © 2015 jun osugi et al.
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آدرس
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department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan, department of regenerative surgery,school of medicine,fukushima medical university, Japan
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Authors
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