Hypoxia-Inducible Factor-1 α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients

Objectives. this research aimed to determine the association between hypoxia-inducible factor-1α (hif-1α) expression and laryngeal squamous cell carcinoma clinical stage. methods. we retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (lscc) patients from 2011 to 2014. hif-1α expression was analyzed by immunohistochemistry using an anti-hif-1α mouse monoclonal antibody. the association between hif-1α expression and clinical stage was analyzed using the chi square test. results. the glottis was the predominant site of laryngeal squamous cell carcinoma occurrence,and 43/47 (91.5%) patients presented at an advanced stage. of the advanced stage patients,27/43 stained positive for hif-1α expression and 16/43 stained negative. of the early stage patients,2/4 stained positive for hif-1α expression and 2/4 stained negative. statistical analysis did not demonstrate significant association of hif-1α expression. conclusion. there was no statistically significant association between hif-1α expression and the clinical stage or histological differentiation of lscc. � 2016 agus surono et al.