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Adiponectin and leptin metabolic biomarkers in chinese children and adolescents
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نویسنده
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mi j. ,munkonda m.n. ,li m. ,zhang m.-x. ,zhao x.-y. ,fouejeu p.c.w. ,cianflone k.
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منبع
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journal of obesity - 2010 - دوره : 2010 - شماره : 0
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چکیده
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Objective. to evaluate leptin and adiponectin as biomarkers of metabolic syndrome (ms) risk factors even in nonobese children/adolescents. methods. serum leptin,adiponectin,leptin:adiponectin ratio,lipids,glucose,and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of chinese children/adolescents (n=3505,6-18 years,1722 girls and 1783 boys). results. leptin concentration increased while adiponectin decreased with obesity,both were influenced by pubertal development. central obesity had an additive effect on leptin levels (above obesity alone). leptin/adiponectin increased 8.4-fold and 3.2-fold in overweight/obesity,and 15.8- and 4.5-fold with obesity plus ms,in early and late puberty,respectively. even in normal weight children/adolescents,higher leptin and lower adiponectin concentrations associated with increased risk profile. conversely,overweight/obese with lower leptin or higher adiponectin concentrations had a less compromised metabolic profile. conclusion. leptin,adiponectin,and leptin:adiponectin ratio are informative biomarkers for obesity,central obesity,ms,and abnormal metabolic profile even in normal weight children/adolescents. © 2010 jie mi et al.
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آدرس
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department of epidemiology,capital institute of pediatrics, China, department of endocrinology,peking union medical college hospital,chinese academy of medical sciences, China, centre de recherche institut,universitaire de cardiologie et pneumologie de quebec,université laval,2725 chemin ste-foy,québec, Canada, department of epidemiology,capital institute of pediatrics, China, department of epidemiology,capital institute of pediatrics, China, laboratory of nutrition and nutritional biochemistry,university of yaoundé, Cameroon, department of endocrinology,peking union medical college hospital,chinese academy of medical sciences, China
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Authors
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