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   Leptin deficiency and its effects on tibial and vertebral bone mechanical properties in mature genetically lean and obese JCR:LA-corpulent rats  
   
نویسنده reimer r.a. ,lamothe j.m. ,zernicke r.f.
منبع journal of obesity - 2012 - دوره : 2012 - شماره : 0
چکیده    Leptin signaling deficient rodents have emerged as models of obesity/insulin resistance syndrome. altered leptin signaling,however,can affect axial and appendicular bone geometrical properties differently,and,thus,we hypothesized that leptin-deficiency would differentially influence mechanical properties of vertebrae and tibiae compared to lean rats. mature (9 mo) leptin receptor deficient obese (c p / c p; n = 8) and lean (+ / ?; n = 7) male jcr:la-corpulent rats were used to test that hypothesis. tibiae and the sixth lumbar vertebrae (l 6) were scanned with micro-ct and were broken in three point-bending (tibiae) or axial loading (l 6). supporting the hypothesis,vertebrae and tibiae were differentially affected by leptin signaling deficiency. tibiae,but not vertebrae,were significantly shorter in obese rats and achieved a significantly greater load (>18),displacement (>15),and stress (>18) at the proportional limit,relative to the lean rats. conversely,l 6 in obese rats had significantly reduced displacement (>25) and strain (>32) at proportional limit,relative to the lean rats. those combined results suggest that the etiology and duration of obesity may be important determinants of bone mechanical properties,and axial and appendicular bones may be affected differently. © 2012 raylene a. reimer et al.
آدرس faculties of kinesiology and medicine,university of calgary,2500 university drive nw,calgary,ab t2n 1n4,canada,department of biochemistry and molecular biology,faculty of medicine,university of calgary,calgary, Canada, faculties of kinesiology and medicine,university of calgary,2500 university drive nw,calgary,ab t2n 1n4,canada,department of biochemistry and molecular biology,faculty of medicine,university of calgary,calgary, Canada, faculties of kinesiology and medicine,university of calgary,2500 university drive nw,calgary,ab t2n 1n4,canada,department of biochemistry and molecular biology,faculty of medicine,university of calgary,calgary,ab t2n 4n1,canada,departments of orthopaedic surgery and biomedical engineering,school of kinesiology,university of michigan,ann arbor, United States
 
     
   
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