Impact of the -174 G > C IL-6 polymorphism on bioelectrical parameters in obese subjects after laparoscopic adjustable gastric banding

Background. recent data demonstrated that the -174 g>c il-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (lagb) surgery. objective. we investigated the impact of -174 g>c il-6 polymorphism on weight loss,body composition,and fluid distribution changes in obese subjects after lagb. design and outcome measures. twenty obese subjects were selected and studied at baseline and 3 months after lagb. genetic assessment of -174 g>c il-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed. results. at baseline,c(+) carriers had a lower extracellular water (ecw) and higher intra-cw,phase angle (pa),reactance x c,and x c /height. lagb surgery determined significant reductions in weight and bmi. after lagb,in c(-) carriers,significant decreases in weight,bmi,and ecw and increases in bcm,bcmi,icw,pa,and x c /h were highlighted. in c(+) carriers,significant reductions in weight,bmi,icw,and pa and increases in ecw,na/k,resistance (r),and r/height were obtained. significant higher reductions in bmi and x c /h were observed in c(+) with respect to c(-) carriers. conclusions. genotyping of genetic variants,for example,the -174 g>c polymorphism of il-6,gives the opportunity to predict therapeutic response,in terms of body composition outcomes after lagb. © 2012 laura di renzo et al.