Effects of Roux-en-Y gastric bypass on fasting and postprandial levels of the inflammatory markers YKL-40 and MCP-1 in patients with type 2 diabetes and glucose tolerant subjects

Background. the inflammatory markers ykl-40 and monocyte chemoattractant protein-1 (mcp-1) are elevated in morbidly obese patients and decline after weight loss. the objective of our study was to investigate the possible changes of ykl-40 and mcp-1,in both the fasting and the postprandial states,following roux-en-y gastric bypass (rygb) in subjects with type 2 diabetes (t2d) and normal glucose tolerance (ngt). methods. ten obese patients with t2d and 10 subjects with ngt were examined in the fasting state and after a standard meal prior to and after (1 week,3 months,and 1 year) rygb. results. fasting state mcp-1 levels decreased after rygb in both groups (p values < 0.0001) whereas fasting ykl-40 levels were unchanged (p values ≥ 0.120). postprandial mcp-1 levels showed a tendency towards a decrease on most study days; however,the changes were only significant at 1 week (p=0.001) and 1 yr (p<0.0001) in the t2d group and at 3 mo after rygb in the ngt group (p=0.009). ykl-40 levels showed a slight,postprandial suppression on all study days in the t2d group (all p values ≤ 0.021). conclusions. fasting mcp-1 levels,but not ykl-40 levels,decrease after rygb in subjects with t2d and ngt. postprandial changes of inflammatory markers are discrete and inconsistent. © 2013 stine brinkløv thomsen et al.